Cytochrome P450 2B6
Also known as: CYP2B6
Cytochrome P450 enzyme that metabolises efavirenz, bupropion, methadone and cyclophosphamide.
CYP2B6 induction (e.g. rifampicin, phenobarbital) lowers efavirenz and bupropion concentrations; inhibition increases exposure.
Substrates: efavirenz, bupropion, methadone, cyclophosphamide, sibutramine.
Inhibitors: clopidogrel, ticlopidine, voriconazole.
Inducers: rifampicin, phenobarbital, carbamazepine, phenytoin.
Relevant in antiretroviral therapy: rifampicin markedly lowers efavirenz concentrations.
DailyMed/FDA (NIH/NLM) — approved labels (efavirenz, bupropion); EMC-UK (MHRA) — SmPC
