Dopamine transporter (SLC6A3)
Also known as: DAT, SLC6A3, dopamine-transporter
Uptake transporter (SLC6A3) located on dopaminergic terminals, which recycles dopamine into the neurone. It is the therapeutic target of psychostimulants (methylphenidate) and cocaine.
DAT inhibition raises synaptic dopamine; drugs that inhibit DAT (methylphenidate, bupropion) can interact with other dopaminergic agents.
Important in ADHD and substance dependence: bupropion (weak DAT and NET inhibitor) may reduce efficacy of dopaminergic drugs and potentiate seizures at high doses.
