Transporters

NET

Norepinephrine transporter (SLC6A2)

Also known as: NET, SLC6A2, NETT, norepinephrine-transporter

What it is

Uptake transporter (SLC6A2) located on noradrenergic terminals, which recycles norepinephrine (adrenaline) into the neurone. It is targeted by SNRIs (venlafaxine, duloxetine) and atomoxetine.

Role in interactions

NET inhibition raises synaptic norepinephrine; serotonergic drugs that also inhibit NET (venlafaxine, duloxetine) may cause hypertension through noradrenergic potentiation.

Common substrates2

norepinephrine (adrenaline)epinephrine

Inhibitors7

venlafaxine duloxetine mirtazapine (weak)atomoxetinedesipraminenortriptylinebupropion (weak)

Inducers1

there are no clinically relevant inducers

Clinical notes

Venlafaxine and duloxetine inhibit both SERT and NET (dual action); mirtazapine has a different mechanism (α2 antagonism) but additive noradrenergic effects.