Quetiapine is an atypical antipsychotic used for schizophrenia, bipolar disorder, and as adjunct in major depression.
Also known as: quetiapine, seroquel
D2, 5-HT2A, H1 and α1 antagonist. Norquetiapine (metabolite) inhibits noradrenaline reuptake.
Region-dependent D2 antagonism. High H1 affinity (sedation) and α1 (orthostatic hypotension). Norquetiapine contributes to antidepressant effect.
Rapid oral absorption. Bioavailability: 100%. Food increases absorption.
Metabolised by CYP3A4. Norquetiapine (active metabolite).
6-7 h (quetiapine); 12 h (norquetiapine).
No documented drug–drug interactions for this medicine.
Alcohol adds intense sedation and orthostatic hypotension of quetiapine — falls and accidents risk.
Avoid alcohol, especially during dose titration.
EMC-UK — Quetiapine SmPC 4.5/4.7 (alcohol).
No documented disease interactions.
No documented pregnancy or breastfeeding information.
Clinical and educational support tool. The information does not replace a medical prescription or the opinion of a qualified healthcare professional.
Medicines from the same therapeutic group (ATC classification) or the same pharmacological class.
